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Target
Phenylalanine--tRNA ligase, mitochondrial
Ligand
BDBM50140726
Substrate
n/a
Meas. Tech.
ChEMBL_154870 (CHEMBL768844)
IC50
4900±n/a nM
Citation
 Yu, XY; Finn, J; Hill, JM; Wang, ZG; Keith, D; Silverman, J; Oliver, N A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity. Bioorg Med Chem Lett 14:1343-6 (2004) [PubMed]  Article 
Target
Name:
Phenylalanine--tRNA ligase, mitochondrial
Synonyms:
FARS1 | FARS2 | PheRS | Phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase mitochondrial | Phenylalanyl-tRNA synthetase, mitochondrial | SYFM_HUMAN
Type:
PROTEIN
Mol. Mass.:
52367.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154870
Residue:
451
Sequence:
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF
  
Inhibitor
Name:
BDBM50140726
Synonyms:
13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-phenyl-(1S,12R,13S,14R)-10,15-dioxatetracyclo[7.6.0.01,12.03,8]pentadeca-3(8),4,6-triene-13-carboxamide | CHEMBL25737
Type:
Small organic molecule
Emp. Form.:
C26H19Cl2NO5
Mol. Mass.:
496.339
SMILES:
OC1c2ccccc2C2OC(=O)[C@@H]3[C@@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Structure:
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