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Target
Phenylalanine--tRNA ligase, mitochondrial
Ligand
BDBM50140730
Substrate
n/a
Meas. Tech.
ChEMBL_154870 (CHEMBL768844)
IC50
11000±n/a nM
Citation
 Yu, XY; Finn, J; Hill, JM; Wang, ZG; Keith, D; Silverman, J; Oliver, N A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity. Bioorg Med Chem Lett 14:1343-6 (2004) [PubMed]  Article 
Target
Name:
Phenylalanine--tRNA ligase, mitochondrial
Synonyms:
FARS1 | FARS2 | PheRS | Phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase mitochondrial | Phenylalanyl-tRNA synthetase, mitochondrial | SYFM_HUMAN
Type:
PROTEIN
Mol. Mass.:
52367.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154870
Residue:
451
Sequence:
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF
  
Inhibitor
Name:
BDBM50140730
Synonyms:
4-(3,4-dichlorophenylcarbamoyl)-1',3'-dioxo-5-phenylspiro[tetrahydrofuran-2,2'-(2',3'-dihydro-1'H-indene)]-3-carboxylic acid | CHEMBL29865
Type:
Small organic molecule
Emp. Form.:
C26H17Cl2NO6
Mol. Mass.:
510.322
SMILES:
OC(=O)[C@@H]1[C@@H]([C@@H](OC11C(=O)c2ccccc2C1=O)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Structure:
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