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Target
Proline-rich acidic protein 1
Ligand
BDBM50574990
Substrate
n/a
Meas. Tech.
ChEMBL_2123777 (CHEMBL4833010)
IC50
19±n/a nM
Citation
 Wang, C; Qu, L; Li, S; Yin, F; Ji, L; Peng, W; Luo, H; Lu, D; Liu, X; Chen, X; Kong, L; Wang, X Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA. J Med Chem 64:12630-12650 (2021) [PubMed]  Article 
Target
Name:
Proline-rich acidic protein 1
Synonyms:
Epididymis tissue protein Li 178 | PRAP1 | PRAP1_HUMAN | Proline-rich acidic protein 1 | UPA | UPA | Uterine-specific proline-rich acidic protein
Type:
PROTEIN
Mol. Mass.:
17201.93
Organism:
Homo sapiens
Description:
ChEMBL_120466
Residue:
151
Sequence:
MRRLLLVTSLVVVLLWEAGAVPAPKVPIKMQVKHWPSEQDPEKAWGARVVEPPEKDDQLVVLFPVQKPKLLTTEEKPRGQGRGPILPGTKAWMETEDTLGHVLSPEPDHDSLYHPPPEEDQGEERPRLWVMPNHQVLLGPEEDQDHIYHPQ
  
Inhibitor
Name:
BDBM50574990
Synonyms:
CHEMBL4849327
Type:
Small organic molecule
Emp. Form.:
C47H47FN8O5
Mol. Mass.:
822.9251
SMILES:
CCN(C(=O)C(C)=C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F
Structure:
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