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Target
Stromelysin-1
Ligand
BDBM50141575
Substrate
n/a
Meas. Tech.
ChEBML_104878
Ki
0.430000±n/a nM
Citation
 Tsukida, T; Moriyama, H; Inoue, Y; Kondo, H; Yoshino, K; Nishimura, S Synthesis and biological activity of selective azasugar-based TACE inhibitors. Bioorg Med Chem Lett 14:1569-72 (2004) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50141575
Synonyms:
(2R,3R,4R,5R)-1-(4-But-2-ynyloxy-benzenesulfonyl)-4,5-dihydroxy-3-methoxy-piperidine-2-carboxylic acid hydroxyamide | CHEMBL291264
Type:
Small organic molecule
Emp. Form.:
C17H22N2O8S
Mol. Mass.:
414.43
SMILES:
CO[C@H]1[C@H](O)[C@H](O)CN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CC)cc1
Structure:
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