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Target
Tumor necrosis factor
Ligand
BDBM50575304
Substrate
n/a
Meas. Tech.
ChEMBL_2124822 (CHEMBL4834055)
Kd
5100±n/a nM
Citation
 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries. J Med Chem 64:17496-17510 (2021) [PubMed]  Article 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM50575304
Synonyms:
CHEMBL4877313
Type:
Small organic molecule
Emp. Form.:
C18H14FIN2O4
Mol. Mass.:
468.2176
SMILES:
OC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2c(F)cccc2[nH]1 |r|
Structure:
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