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Target
RNA-directed RNA polymerase
Ligand
BDBM50137468
Substrate
n/a
Meas. Tech.
ChEBML_143775
IC50
7000±n/a nM
Citation
 Beaulieu, PL; Bös, M; Bousquet, Y; DeRoy, P; Fazal, G; Gauthier, J; Gillard, J; Goulet, S; McKercher, G; Poupart, MA; Valois, S; Kukolj, G Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency. Bioorg Med Chem Lett 14:967-71 (2004) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50137468
Synonyms:
1-Cyclohexyl-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid 3,4-dimethoxy-benzylamide | CHEMBL366941
Type:
Small organic molecule
Emp. Form.:
C28H30N4O3
Mol. Mass.:
470.5628
SMILES:
COc1ccc(CNC(=O)c2ccc3n(C4CCCCC4)c(nc3c2)-c2ccccn2)cc1OC
Structure:
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