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Target
Carboxypeptidase B2
Ligand
BDBM50575758
Substrate
n/a
Meas. Tech.
ChEMBL_2125968 (CHEMBL4835313)
IC50
183±n/a nM
Citation
 Schaffner, AP; Sansilvestri-Morel, P; Despaux, N; Ruano, E; Persigand, T; Rupin, A; Mennecier, P; Vallez, MO; Raimbaud, E; Desos, P; Gloanec, P Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa). J Med Chem 64:3897-3910 (2021) [PubMed]  Article 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM50575758
Synonyms:
CHEMBL4847492
Type:
Small organic molecule
Emp. Form.:
C16H24ClN2O4P
Mol. Mass.:
374.8
SMILES:
NCCCCC1(CN(Cc2ccc(Cl)cc2)CCP1(O)=O)C(O)=O
Structure:
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