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Target
Retinoic acid receptor RXR-gamma
Ligand
BDBM50575871
Substrate
n/a
Meas. Tech.
ChEMBL_2126072 (CHEMBL4835417)
EC50
50±n/a nM
Citation
 Schierle, S; Chaikuad, A; Lillich, FF; Ni, X; Woltersdorf, S; Schallmayer, E; Renelt, B; Ronchetti, R; Knapp, S; Proschak, E; Merk, D Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics. J Med Chem 64:5123-5136 (2021) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-gamma
Synonyms:
NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha
Type:
PROTEIN
Mol. Mass.:
50878.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_197216
Residue:
463
Sequence:
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
  
Inhibitor
Name:
BDBM50575871
Synonyms:
CHEMBL4855847
Type:
Small organic molecule
Emp. Form.:
C20H13F6NO3
Mol. Mass.:
429.3125
SMILES:
OC(=O)CCc1nc(c(o1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)-c1ccccc1
Structure:
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