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Target
M-phase inducer phosphatase 2
Ligand
BDBM50142547
Substrate
n/a
Meas. Tech.
ChEBML_49031
IC50
8400±n/a nM
Citation
 Bäurle, S; Blume, T; Günther, J; Henschel, D; Hillig, RC; Husemann, M; Mengel, A; Parchmann, C; Schmid, E; Skuballa, W Design and synthesis of macrocyclic inhibitors of phosphatase cdc25B. Bioorg Med Chem Lett 14:1673-7 (2004) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50142547
Synonyms:
(Z)-(2R,5R,6R,13S)-13-Allyl-5-((R)-1,5-dimethyl-hexyl)-13-hydroxy-6,10-dimethyl-tricyclo[13.2.2.0*2,6*]nonadeca-1(17),9,15,18-tetraene-17-carboxylic acid | CHEMBL46608
Type:
Small organic molecule
Emp. Form.:
C33H50O3
Mol. Mass.:
494.7483
SMILES:
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2c3ccc(C[C@@](O)(CC=C)CC\C(C)=C/CC[C@]12C)cc3C(O)=O |c:25|
Structure:
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