Reaction Details Report a problem with these data
Target
Glycine N-methyltransferase
Ligand
BDBM50576433
Substrate
n/a
Meas. Tech.
ChEMBL_2127252 (CHEMBL4836597)
IC50
390±n/a nM
Citation
 Bobi?eva, O; Bobrovs, R; Ka?epe, I; Patetko, L; Kalni??, G; ?i?ovs, M; Bula, AL; Gri Nberga, S; Borodu??is, MR; Ramata-Stunda, A; Rostoks, N; Jirgensons, A; Ta Rs, K; Jaudzems, K Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate. ACS Med Chem Lett 12:1102-1107 (2021) [PubMed]  Article 
Target
Name:
Glycine N-methyltransferase
Synonyms:
2.1.1.20 | GNMT | GNMT_HUMAN | Glycine N-methyltransferase
Type:
PROTEIN
Mol. Mass.:
32744.92
Organism:
Homo sapiens
Description:
ChEMBL_119045
Residue:
295
Sequence:
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSKFRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD
  
Inhibitor
Name:
BDBM50576433
Synonyms:
CHEMBL4869943
Type:
Small organic molecule
Emp. Form.:
C14H18N8O3S
Mol. Mass.:
378.41
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSCCc2c[nH]nn2)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: