Reaction Details Report a problem with these data
Target
Eukaryotic initiation factor 4A-I
Ligand
BDBM50576672
Substrate
n/a
Meas. Tech.
ChEMBL_2127676 (CHEMBL4837021)
IC50
2.3±n/a nM
Citation
 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH 1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties. Bioorg Med Chem Lett 47:0 (2021) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-I
Synonyms:
ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I
Type:
PROTEIN
Mol. Mass.:
46146.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_864983
Residue:
406
Sequence:
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
  
Inhibitor
Name:
BDBM50576672
Synonyms:
CHEMBL4857096
Type:
Small organic molecule
Emp. Form.:
C28H29BrN2O5
Mol. Mass.:
553.444
SMILES:
COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CNC4COC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r|
Structure:
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