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Target
POU domain, class 2, transcription factor 1
Ligand
BDBM50576849
Substrate
n/a
Meas. Tech.
ChEMBL_2127960 (CHEMBL4837389)
IC50
>50000±n/a nM
Citation
 Kumar, S; Jaipuri, FA; Waldo, JP; Potturi, H; Marcinowicz, A; Adams, J; Van Allen, C; Zhuang, H; Vahanian, N; Link, C; Brincks, EL; Mautino, MR Discovery of indoximod prodrugs and characterization of clinical candidate NLG802. Eur J Med Chem 198:0 (2020) [PubMed]  Article 
Target
Name:
POU domain, class 2, transcription factor 1
Synonyms:
NF-A1 | OCT1 | OCT1 | OTF-1 | OTF1 | Oct-1 | Octamer-binding protein 1 | Octamer-binding transcription factor 1 | PO2F1_HUMAN | POU domain, class 2, transcription factor 1 | POU2F1
Type:
PROTEIN
Mol. Mass.:
76471.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109690
Residue:
743
Sequence:
MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQNSLFTVASASGAASTTTTASKAQ
  
Inhibitor
Name:
BDBM50576849
Synonyms:
CHEMBL4876008
Type:
Small organic molecule
Emp. Form.:
C20H30ClN3O3
Mol. Mass.:
395.924
SMILES:
Cl.CCOC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H](N)CC(C)C |r|
Structure:
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