Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50144378
Substrate
n/a
Meas. Tech.
ChEBML_196438
IC50
41±n/a nM
Citation
Kath, JC; DiRico, AP; Gladue, RP; Martin, WH; McElroy, EB; Stock, IA; Tylaska, LA; Zheng, D The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template. Bioorg Med Chem Lett 14:2163-7 (2004) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
RENI_RAT | Ren | Ren1
Type:
PROTEIN
Mol. Mass.:
44272.67
Organism:
Rattus norvegicus
Description:
ChEMBL_222765
Residue:
402
Sequence:
MGGRRMPLWALLLLWTSCSFSLPTDTASFGRILLKKMPSVREILEERGVDMTRISAEWGEFIKKSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYTACEIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGGIIVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRESHLLGGEVVLGGSDPQHYQGNFHYVSISKAGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANNYVVNCSQVPTLPDISFYLGGRTYTLSNMDYVQKNPFRNDDLCILALQGLDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
Inhibitor
Name:
BDBM50144378
Synonyms:
5-Chloro-1H-indole-2-carboxylic acid ((1S,2S,4S)-6-chloro-1-cyclohexylmethyl-2-hydroxy-4-methylcarbamoyl-hept-6-enyl)-amide | CHEMBL302095
Type:
Small organic molecule
Emp. Form.:
C25H33Cl2N3O3
Mol. Mass.:
494.454
SMILES:
CNC(=O)[C@@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)CC(Cl)=C