Reaction Details Report a problem with these data
Target
Tryptase beta-2/delta/gamma
Ligand
BDBM50144531
Substrate
n/a
Meas. Tech.
ChEMBL_210690 (CHEMBL817288)
IC50
29±n/a nM
Citation
Bisacchi, GS; Slusarchyk, WA; Bolton, SA; Hartl, KS; Jacobs, G; Mathur, A; Meng, W; Ogletree, ML; Pi, Z; Sutton, JC; Treuner, U; Zahler, R; Zhao, G; Seiler, SM Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase. Bioorg Med Chem Lett 14:2227-31 (2004) [PubMed] Article
More Info.:
Target
Name:
Tryptase beta-2/delta/gamma
Synonyms:
Tryptase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1510505
Components:
This complex has 3 components.
Component 1
Name:
Tryptase gamma
Synonyms:
PRSS31 | Serine protease 31 | TMT | TPSG1 | TRYG1_HUMAN | Transmembrane tryptase | Tryptase | Tryptase gamma | Tryptase gamma heavy chain | Tryptase gamma light chain
Type:
PROTEIN
Mol. Mass.:
33817.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210833
Residue:
321
Sequence:
MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRMHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDACQDDSGGPLVCQVNGAWVQAGTVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGLFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD
Component 2
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
Component 3
Name:
Tryptase delta
Synonyms:
Delta-tryptase | HmMCP-3-like tryptase III | Mast cell mMCP-7-like | TPSD1 | TRYD_HUMAN | Tryptase delta | Tryptase-3
Type:
PROTEIN
Mol. Mass.:
26578.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104777
Residue:
242
Sequence:
MLLLAPQMLSLLLLALPVLASPAYVAPAPGQALQQTGIVGGQEAPRSKWPWQVSLRVRGPYWMHFCGGSLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYIIQTGADIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPYPLKEVEVPVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVNGT
Inhibitor
Name:
BDBM50144531
Synonyms:
4-((2S,3R)-2-Carboxy-4-oxo-3-piperidin-4-ylmethyl-azetidine-1-carbonyl)-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester | CHEMBL72279
Type:
Small organic molecule
Emp. Form.:
C23H38N4O6
Mol. Mass.:
466.571
SMILES:
CC(C)C(OC(=O)N1CCN(CC1)C(=O)N1[C@@H]([C@@H](CC2CCNCC2)C1=O)C(O)=O)C(C)C