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Target
Serine/threonine-protein kinase TNNI3K
Ligand
BDBM50578225
Substrate
n/a
Meas. Tech.
ChEMBL_2132298 (CHEMBL4841813)
Ki
13±n/a nM
Citation
 Patterson, JR; Graves, AP; Stoy, P; Cheung, M; Desai, TA; Fries, H; Gatto, GJ; Holt, DA; Shewchuk, L; Totoritis, R; Wang, L; Kallander, LS Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38?, and B-Raf. J Med Chem 64:15651-15670 (2021) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase TNNI3K
Synonyms:
2.7.11.1 | Cardiac ankyrin repeat kinase | Cark | Serine/threonine-protein kinase TNNI3K | TNI3K_MOUSE | TNNI3-interacting kinase | Tnni3k
Type:
PROTEIN
Mol. Mass.:
92577.45
Organism:
Mus musculus
Description:
ChEMBL_120431
Residue:
834
Sequence:
MGNYKSRPTQTCSDEWKKKVSESYAIIIERLEDDLQIKENEFQELRHIFGSDEAFSEVSLNYRTERGLSLLHLCCACGGNKSHIRALMLKGLRPSRLTRNGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQSDLEVQPHVINIYGDTPLHLACYNGNFEVAKEIVHVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNINHRGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPSRFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKLEECLCNVELMSPASSNSSGSLSPSSSSDCLLSRGGPGRSHVAALRSRFELEYALNARSYTGWPQSVGTHTNPGLSLEEMNRGAQYSAVDKYGYVSDPMSPMHLHSRRNSGSFEDGN
  
Inhibitor
Name:
BDBM50578225
Synonyms:
CHEMBL4869303
Type:
Small organic molecule
Emp. Form.:
C19H14Cl2F3N5O2
Mol. Mass.:
472.248
SMILES:
CNc1cc(Oc2c(Cl)cc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2Cl)ncn1
Structure:
Search PDB for entries with ligand similarity: