Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 4
Ligand
BDBM50578268
Substrate
n/a
Meas. Tech.
ChEMBL_2132453 (CHEMBL4841968)
Ki
0.033000±n/a nM
Citation
 Konieczny, A; Conrad, M; Ertl, FJ; Gleixner, J; Gattor, AO; Grätz, L; Schmidt, MF; Neu, E; Horn, AHC; Wifling, D; Gmeiner, P; Clark, T; Sticht, H; Keller, M N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y J Med Chem 64:16746-16769 (2021) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 4
Synonyms:
NPY-Y4 | NPY4-R | NPY4R | NPY4R_HUMAN | PP1 | PPYR1 | Pancreatic polypeptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42207.58
Organism:
Homo sapiens (Human)
Description:
NPY-Y4 PPYR1 HUMAN::P50391
Residue:
375
Sequence:
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
  
Inhibitor
Name:
BDBM50578268
Synonyms:
CHEMBL4856311
Type:
Small organic molecule
Emp. Form.:
C53H81N19O10
Mol. Mass.:
1144.3315
SMILES:
CC(C)C[C@H](NC(=O)[C@@H]1CCCNC(=N)NC(=O)NCCCCNC(=O)CCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|
Structure:
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