Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50579542
Substrate
n/a
Meas. Tech.
ChEMBL_2135623 (CHEMBL4845233)
IC50
>10000±n/a nM
Citation
 Yang, L; Zhang, W; Qiu, Q; Su, Z; Tang, M; Bai, P; Si, W; Zhu, Z; Liu, Y; Yang, J; Kuang, S; Liu, J; Yan, W; Shi, M; Ye, H; Yang, Z; Chen, L Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity. J Med Chem 64:15379-15401 (2021) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50579542
Synonyms:
CHEMBL4878408
Type:
Small organic molecule
Emp. Form.:
C22H26N4O4
Mol. Mass.:
410.4662
SMILES:
COc1ccc(cc1OC(C(C)C)C(=O)NO)N(C)c1nc(C)nc2ccccc12
Structure:
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