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Target
Beta-secretase 2
Ligand
BDBM50579806
Substrate
n/a
Meas. Tech.
ChEMBL_2145464 (CHEMBL5029744)
IC50
309±n/a nM
Citation
 Rombouts, FJR; Kusakabe, KI; Alexander, R; Austin, N; Borghys, H; De Cleyn, M; Dhuyvetter, D; Gijsen, HJM; Hrupka, B; Jacobs, T; Jerhaoui, S; Lammens, L; Leclercq, L; Tsubone, K; Ueno, T; Morimoto, K; Einaru, S; Sumiyoshi, H; Van den Bergh, A; Vos, A; Surkyn, M; Teisman, A; Moechars, D JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J Med Chem 64:14175-14191 (2021) [PubMed]  Article 
Target
Name:
Beta-secretase 2
Synonyms:
BACE2_MOUSE | Bace2 | Beta-secretase 2 (BACE2)
Type:
Enzyme
Mol. Mass.:
55787.27
Organism:
Mus musculus (Mouse)
Description:
Q9JL18
Residue:
514
Sequence:
MGALLRALLLLVLAQWLLSAVPALAPAPFTLPLQVAGATNHRASAVPGLGTPELPRADGLALALEPVRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIEGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLLPLHCRHAPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM50579806
Synonyms:
CHEMBL5092328
Type:
Small organic molecule
Emp. Form.:
C22H22F4N4O5S
Mol. Mass.:
530.492
SMILES:
CCS(=O)(=O)[C@]1(C)CC[C@](CF)(N=C1N)c1cc(NC(=O)c2cc3OC(F)(F)Oc3cn2)ccc1F |r,c:12|
Structure:
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