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Target
Carbonic anhydrase 5B, mitochondrial
Ligand
BDBM50580098
Substrate
n/a
Meas. Tech.
ChEMBL_2146935 (CHEMBL5031281)
Ki
54±n/a nM
Citation
 Plyasova, AA; Berrino, E; Khan, II; Veselovsky, AV; Pokrovsky, VS; Angeli, A; Ferraroni, M; Supuran, CT; Pokrovskaya, MV; Alexandrova, SS; Gladilina, YA; Sokolov, NN; Hilal, A; Carta, F; Zhdanov, DD Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors. J Med Chem 64:11432-11444 (2021) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 5B, mitochondrial
Synonyms:
CA-VB | CA5B | CAH5B_HUMAN | Carbonate dehydratase VB | Carbonic Anhydrase VB | Carbonic anhydrase 5B (CA VB) | Carbonic anhydrase 5B, mitochondrial | Carbonic anhydrase 5B, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VB (CA VB)
Type:
Enzyme
Mol. Mass.:
36440.83
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme
Residue:
317
Sequence:
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP
  
Inhibitor
Name:
BDBM50580098
Synonyms:
CHEMBL5075948
Type:
Small organic molecule
Emp. Form.:
C20H22N6O8S
Mol. Mass.:
506.489
SMILES:
Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(COC(=O)c3ccc(cc3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r|
Structure:
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