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Target
Carbonic anhydrase 7
Ligand
BDBM50580101
Substrate
n/a
Meas. Tech.
ChEMBL_2146936 (CHEMBL5031282)
Ki
11±n/a nM
Citation
 Plyasova, AA; Berrino, E; Khan, II; Veselovsky, AV; Pokrovsky, VS; Angeli, A; Ferraroni, M; Supuran, CT; Pokrovskaya, MV; Alexandrova, SS; Gladilina, YA; Sokolov, NN; Hilal, A; Carta, F; Zhdanov, DD Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors. J Med Chem 64:11432-11444 (2021) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50580101
Synonyms:
CHEMBL5081179
Type:
Small organic molecule
Emp. Form.:
C21H21N5O8S
Mol. Mass.:
503.485
SMILES:
Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(COc3ccc4OS(=O)(=O)C=Cc4c3)nn2)c(=O)[nH]c1=O |r,c:25|
Structure:
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