Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50036738
Substrate
n/a
Meas. Tech.
ChEMBL_2147395 (CHEMBL5031741)
Ki
2.0±n/a nM
Citation
 Barbaraci, C; Giurdanella, G; Leotta, CG; Longo, A; Amata, E; Dichiara, M; Pasquinucci, L; Turnaturi, R; Prezzavento, O; Cacciatore, I; Zuccarello, E; Lupo, G; Pitari, GM; Anfuso, CD; Marrazzo, A Haloperidol Metabolite II Valproate Ester ( J Med Chem 64:13622-13632 (2021) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50036738
Synonyms:
(R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-hydroxy-butyl]-piperidin-4-ol | CHEMBL129159
Type:
Small organic molecule
Emp. Form.:
C21H25ClFNO2
Mol. Mass.:
377.88
SMILES:
O[C@H](CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)c1ccc(F)cc1
Structure:
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