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Target
Retinoid isomerohydrolase
Ligand
BDBM50546390
Substrate
n/a
Meas. Tech.
ChEMBL_2148422 (CHEMBL5032820)
IC50
323±n/a nM
Citation
 Blum, E; Zhang, J; Zaluski, J; Einstein, DE; Korshin, EE; Kubas, A; Gruzman, A; Tochtrop, GP; Kiser, PD; Palczewski, K Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem 64:8287-8302 (2021) [PubMed]  Article 
Target
Name:
Retinoid isomerohydrolase
Synonyms:
Lutein isomerase | Meso-zeaxanthin isomerase | RPE65 | RPE65_BOVIN | Retinal pigment epithelium-specific 65 kDa protein | Retinoid isomerohydrolase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60942.63
Organism:
Bos taurus (Bovine)
Description:
Q28175
Residue:
533
Sequence:
MSSQVEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFPDPCKNIFSRFFSYFRGVEVTDNALVNIYPVGEDYYACTETNFITKVNPETLETIKQVDLCNYVSVNGATAHPHIENDGTVYNIGNCFGKNFSIAYNIVKIPPLQADKEDPISKSEIVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDCFESNETMGVWLHIADKKRKKYINNKYRTSPFNLFHHINTYEDHEFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARKAPQPEVRRYVLPLNIDKADTGKNLVTLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINYQKYGGKPYTYAYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS
  
Inhibitor
Name:
BDBM50546390
Synonyms:
CHEMBL4757869
Type:
Small organic molecule
Emp. Form.:
C19H29NO2
Mol. Mass.:
303.4391
SMILES:
CC1=C(COc2cccc(c2)[C@H](O)CCN)C(C)(C)CCC1 |r,c:1|
Structure:
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