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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50148815
Substrate
n/a
Meas. Tech.
ChEMBL_124228 (CHEMBL733982)
IC50
41600.0±n/a nM
Citation
 Velezheva, VS; Brennan, PJ; Marshakov, VY; Gusev, DV; Lisichkina, IN; Peregudov, AS; Tchernousova, LN; Smirnova, TG; Andreevskaya, SN; Medvedev, AE Novel pyridazino[4,3-b]indoles with dual inhibitory activity against Mycobacterium tuberculosis and monoamine oxidase. J Med Chem 47:3455-61 (2004) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rattus norvegicus (rat)
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM50148815
Synonyms:
4-(2-Fluoro-phenyl)-5-methyl-5H-pyridazino[4,3-b]indol-3-ylamine | CHEMBL116668
Type:
Small organic molecule
Emp. Form.:
C17H13FN4
Mol. Mass.:
292.3103
SMILES:
Cn1c2ccccc2c2nnc(N)c(-c3ccccc3F)c12 |(4.17,-1.29,;3.77,.2,;2.33,.74,;.96,.05,;-.33,.9,;-.25,2.41,;1.12,3.11,;2.42,2.27,;3.89,2.67,;4.61,4.04,;6.14,4.12,;6.99,2.81,;8.52,2.84,;6.27,1.44,;7.1,.14,;6.38,-1.21,;7.19,-2.52,;8.73,-2.45,;9.45,-1.1,;8.64,.2,;9.97,.98,;4.73,1.37,)|
Structure:
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