Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50148821
Substrate
n/a
Meas. Tech.
ChEMBL_123279 (CHEMBL731800)
IC50
100000±n/a nM
Citation
 Velezheva, VS; Brennan, PJ; Marshakov, VY; Gusev, DV; Lisichkina, IN; Peregudov, AS; Tchernousova, LN; Smirnova, TG; Andreevskaya, SN; Medvedev, AE Novel pyridazino[4,3-b]indoles with dual inhibitory activity against Mycobacterium tuberculosis and monoamine oxidase. J Med Chem 47:3455-61 (2004) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA)
Type:
Enzyme
Mol. Mass.:
59515.21
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
526
Sequence:
MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
  
Inhibitor
Name:
BDBM50148821
Synonyms:
5-Ethyl-4-(4-isopropyl-phenyl)-5H-pyridazino[4,3-b]indol-3-ylamine | CHEMBL116801
Type:
Small organic molecule
Emp. Form.:
C21H22N4
Mol. Mass.:
330.4262
SMILES:
CCn1c2ccccc2c2nnc(N)c(-c3ccc(cc3)C(C)C)c12
Structure:
Search PDB for entries with ligand similarity: