Target
C-type lectin domain family 4 member M
Ligand
BDBM50509061
Substrate
n/a
Meas. Tech.
ChEMBL_2149161 (CHEMBL757703)
IC50
37500±n/a nM
Citation
 Chakroun, KTaouai, MPorkolab, VLuczkowiak, JSommer, RCheneau, CMathiron, DBen Maaouia, MAPilard, SAbidi, RMulliť, CFieschi, FCragg, PJHalary, FDelgado, RBenazza, M Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN. J Med Chem 64:14332-14343 (2021) [PubMed]  Article  BDB Entry
Target
Name:
C-type lectin domain family 4 member M
Synonyms:
CD209 antigen-like protein 1 | CD209L | CD209L1 | CD299 | CD_antigen=CD299 | CLEC4M | DC-SIGN-related protein | DC-SIGN2 | DC-SIGNR | Dendritic cell-specific ICAM-3-grabbing non-integrin 2 | L-SIGN | Liver/lymph node-specific ICAM-3-grabbing non-integrin
Type:
PROTEIN
Mol. Mass.:
45339.05
Organism:
Homo sapiens
Description:
ChEMBL_105433
Residue:
399
Sequence:
MSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGALVLQLLSFMLLAGVLVAILVQVSKVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKLQEIYQELTQLKAAVGELPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQRNWHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEPNNSGNEDCAEFSGSGWNDNRCDVDNYWICKKPAACFRDE
  
Inhibitor
Name:
BDBM50509061
Synonyms:
CHEMBL4554703
Type:
Small organic molecule
Emp. Form.:
C128H188N28O36
Mol. Mass.:
2695.0283
SMILES:
CC(C)(C)c1cc2Cc3cc(cc(Cc4cc(cc(Cc5cc(cc(Cc(c1)c2OCCCn1cc(CN(O)C(=O)CCCCCn2cc(CO[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)nn2)nn1)c5OCCCn1cc(CN(O)C(=O)CCCCCn2cc(CO[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)nn2)nn1)C(C)(C)C)c4OCCCn1cc(CN(O)C(=O)CCCCCn2cc(CO[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)nn2)nn1)C(C)(C)C)c3OCCCn1cc(CN(O)C(=O)CCCCCn2cc(CO[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)nn2)nn1)C(C)(C)C |r|
Structure:
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