Target
Urea transporter 1
Ligand
BDBM50580900
Substrate
n/a
Meas. Tech.
ChEMBL_2149291 (CHEMBL5033689)
IC50
600±n/a nM
Citation
 Wang, SXu, YZhao, YZhang, SLi, MLi, XHe, JZhou, HGe, ZLi, RYang, B N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties. Eur J Med Chem 226:0 (2021) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B)
Type:
Protein
Mol. Mass.:
42037.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
384
Sequence:
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
  
Inhibitor
Name:
BDBM50580900
Synonyms:
CHEMBL5081628
Type:
Small organic molecule
Emp. Form.:
C14H9N3O5
Mol. Mass.:
299.2384
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2ccc(=O)[nH]c2c1
Structure:
Search PDB for entries with ligand similarity: