Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50581319
Substrate
n/a
Meas. Tech.
ChEMBL_2150520 (CHEMBL5034982)
EC50
>0.050119±n/a nM
Citation
Durek, T; Kaas, Q; White, AM; Weidmann, J; Fuaad, AA; Cheneval, O; Schroeder, CI; de Veer, SJ; Dellsén, A; Österlund, T; Larsson, N; Knerr, L; Bauer, U; Plowright, AT; Craik, DJ Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework. J Med Chem 64:9906-9915 (2021) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Inhibitor
Name:
BDBM50581319
Synonyms:
BIM-22493 | RM-493 | SETMELANOTIDE | Setmelanotide
Type:
Small organic molecule
Emp. Form.:
C49H68N18O9S2
Mol. Mass.:
1117.309
SMILES:
C[C@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O |r|