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Target
Methionine--tRNA ligase
Ligand
BDBM50149639
Substrate
n/a
Meas. Tech.
ChEMBL_305245 (CHEMBL833503)
IC50
16±n/a nM
Citation
 Jarvest, RL; Armstrong, SA; Berge, JM; Brown, P; Elder, JS; Brown, MJ; Copley, RC; Forrest, AK; Hamprecht, DW; O'Hanlon, PJ; Mitchell, DJ; Rittenhouse, S; Witty, DR Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues. Bioorg Med Chem Lett 14:3937-41 (2004) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase
Synonyms:
Methionyl-tRNA synthetase | SYM_STAAW | metG | metS
Type:
PROTEIN
Mol. Mass.:
74852.92
Organism:
Staphylococcus aureus (strain MW2)
Description:
ChEMBL_305245
Residue:
657
Sequence:
MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPATEEEKEEIPSKPQIDIKDFDKVEIKAATIINAEHVKKSDKLLKIQVDLDSEQRQIVSGIAKFYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
  
Inhibitor
Name:
BDBM50149639
Synonyms:
CHEMBL183110 | N-(1H-Benzoimidazol-2-yl)-N''-(6-ethyl-8-iodo-1,2,3,4-tetrahydro-quinolin-4-yl)-propane-1,3-diamine
Type:
Small organic molecule
Emp. Form.:
C21H26IN5
Mol. Mass.:
475.3691
SMILES:
CCc1cc(I)c2NCCC(NCCCNc3nc4ccccc4[nH]3)c2c1
Structure:
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