Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50149662
Substrate
n/a
Meas. Tech.
ChEMBL_302831 (CHEMBL838621)
Ki
13±n/a nM
Citation
 Huang, CQ; Wilcoxen, KM; Grigoriadis, DE; McCarthy, JR; Chen, C Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists. Bioorg Med Chem Lett 14:3943-7 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50149662
Synonyms:
CHEMBL185055 | [3-(5-Diethylamino-3-methyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C24H36N6
Mol. Mass.:
408.5828
SMILES:
CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)N(CC)CC |(4.17,6.07,;4.75,4.64,;3.82,3.43,;4.4,2,;5.93,1.79,;6.53,.37,;8.06,.16,;3.47,.77,;4.05,-.64,;3.11,-1.85,;3.7,-3.28,;1.6,-1.66,;1.01,-.24,;-.44,.27,;-.41,1.81,;-1.61,2.75,;1.08,2.24,;1.96,.97,;-1.84,-.4,;-1.84,-1.95,;-3.17,-2.72,;-4.5,-1.95,;-4.5,-.4,;-3.17,.37,;-3.18,1.91,;-5.84,-2.72,;-5.84,-4.26,;-7.19,-5.03,;-7.19,-1.95,;-7.16,-.4,)|
Structure:
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