Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50149664
Substrate
n/a
Meas. Tech.
ChEMBL_302831 (CHEMBL838621)
Ki
25±n/a nM
Citation
 Huang, CQ; Wilcoxen, KM; Grigoriadis, DE; McCarthy, JR; Chen, C Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists. Bioorg Med Chem Lett 14:3943-7 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50149664
Synonyms:
CHEMBL184694 | [3-(3-Methoxy-5-methyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C21H29N5O
Mol. Mass.:
367.4879
SMILES:
CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(C)cc1OC |(7.2,-.36,;5.68,-.15,;5.09,1.28,;3.56,1.46,;2.97,2.89,;3.91,4.13,;3.32,5.55,;2.62,.25,;3.21,-1.18,;2.27,-2.39,;2.86,-3.82,;.76,-2.18,;.17,-.76,;-1.28,-.26,;-1.24,1.28,;-2.45,2.21,;.24,1.72,;1.11,.46,;-2.68,-.92,;-2.68,-2.48,;-4.01,-3.25,;-5.34,-2.48,;-6.68,-3.25,;-5.34,-.94,;-4.01,-.15,;-4.02,1.39,;-5.35,2.14,)|
Structure:
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