Reaction Details Report a problem with these data
Target
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Ligand
BDBM50149734
Substrate
n/a
Meas. Tech.
ChEMBL_304888 (CHEMBL877327)
IC50
20000±n/a nM
Citation
Orchard, MG; Neuss, JC; Galley, CM; Carr, A; Porter, DW; Smith, P; Scopes, DI; Haydon, D; Vousden, K; Stubberfield, CR; Young, K; Page, M Rhodanine-3-acetic acid derivatives as inhibitors of fungal protein mannosyl transferase 1 (PMT1). Bioorg Med Chem Lett 14:3975-8 (2004) [PubMed] Article
More Info.:
Target
Name:
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Synonyms:
PMT1 | PMT1_CANAL
Type:
PROTEIN
Mol. Mass.:
99941.72
Organism:
Candida albicans
Description:
ChEMBL_304888
Residue:
877
Sequence:
MAKKPVTPASKVAAKQAAVRSRHQEDVFTLDPLIDPIFQKGELRSYLVTEPSPSVLKKRSIHTKEYWMLSSLLLIAFYVRMYNLSNPNSVVFDEVHFGGFARKYILGTFFMDVHPPLAKMLFGAVGAIGGFKGDFEFKSIGDKFPDSTPYIFMRQFPALLGVGTVILCYLTLRQSGVRPIIAYITTFLLIIENSNVTISRYILLDSPLIFFIAAAIYAWKKFEIQIPFTFGWYRSLLATGIALGLALSSKWVGLFTVAWVGFLCIYQLWFLIGDLSVSTKKIWGHFFARGIILLGVPIALYLGFFAIHFQLLNKEGDGGAFMSSAFRAGLQGNKIPRDITEQVGLGSVVTIRHVDTQGGYLHSHEHFYQTGSKQQQITLYPHLDSNNKWLIEPYNGTIHNETFVPLINGMKIRLKHINTGRRLHSHDEKPPVSERDWQKECSCYGYDGFAGDANDDWVVEIVNYRSQKGEAQTFVKAINTIFRLRHAMTGHYLFSSEVKLPEWGFGQQEVTSASQGKRALTHWYIETNENSILPPSEAKIINYPKLSLWQKVVESHKRMWKINQGLTSHHHWQSSPSEWPLLLRGINYWNKEHKQVYLLGNAVTWWAATLSIITFGTYVLVTVFRWHLGTPLSTNKHVFNFNVQTFSYVLGWALHYLPFFIMGRQLFLHHYLPALYFGILALGHFFEIFTGYLTSRSKYFQQVAFVLVGLFSILSLVFYVNYSSLIYGTPWTKASCELTKPFSGWDYNCGTFFDTLGEYDIQEKSLASESEIPTETVVVEAKQTPKAEPKLAKQDDHIESPAAAEPVEEKEVKEEVEQLAPPLAVDFEEETPKVEDPQVADVDASSNDEKSVEEKQQQEQQQEQEQVEDESVHQVQQ
Inhibitor
Name:
BDBM50149734
Synonyms:
CHEMBL182004 | {5-[1-[4-Benzyloxy-3-(4-methanesulfonyl-benzyloxy)-phenyl]-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C27H23NO7S3
Mol. Mass.:
569.669
SMILES:
CS(=O)(=O)c1ccc(COc2cc(\C=C3/SC(=S)N(CC(O)=O)C3=O)ccc2OCc2ccccc2)cc1