Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Ligand
BDBM50149776
Substrate
n/a
Meas. Tech.
ChEMBL_304888 (CHEMBL877327)
IC50
950.0±n/a nM
Citation
Orchard, MG; Neuss, JC; Galley, CM; Carr, A; Porter, DW; Smith, P; Scopes, DI; Haydon, D; Vousden, K; Stubberfield, CR; Young, K; Page, M Rhodanine-3-acetic acid derivatives as inhibitors of fungal protein mannosyl transferase 1 (PMT1). Bioorg Med Chem Lett 14:3975-8 (2004) [PubMed] Article More Info.:
Target
Name:
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Synonyms:
PMT1 | PMT1_CANAL
Type:
PROTEIN
Mol. Mass.:
99941.72
Organism:
Candida albicans
Description:
ChEMBL_304888
Residue:
877
Sequence:
MAKKPVTPASKVAAKQAAVRSRHQEDVFTLDPLIDPIFQKGELRSYLVTEPSPSVLKKRSIHTKEYWMLSSLLLIAFYVRMYNLSNPNSVVFDEVHFGGFARKYILGTFFMDVHPPLAKMLFGAVGAIGGFKGDFEFKSIGDKFPDSTPYIFMRQFPALLGVGTVILCYLTLRQSGVRPIIAYITTFLLIIENSNVTISRYILLDSPLIFFIAAAIYAWKKFEIQIPFTFGWYRSLLATGIALGLALSSKWVGLFTVAWVGFLCIYQLWFLIGDLSVSTKKIWGHFFARGIILLGVPIALYLGFFAIHFQLLNKEGDGGAFMSSAFRAGLQGNKIPRDITEQVGLGSVVTIRHVDTQGGYLHSHEHFYQTGSKQQQITLYPHLDSNNKWLIEPYNGTIHNETFVPLINGMKIRLKHINTGRRLHSHDEKPPVSERDWQKECSCYGYDGFAGDANDDWVVEIVNYRSQKGEAQTFVKAINTIFRLRHAMTGHYLFSSEVKLPEWGFGQQEVTSASQGKRALTHWYIETNENSILPPSEAKIINYPKLSLWQKVVESHKRMWKINQGLTSHHHWQSSPSEWPLLLRGINYWNKEHKQVYLLGNAVTWWAATLSIITFGTYVLVTVFRWHLGTPLSTNKHVFNFNVQTFSYVLGWALHYLPFFIMGRQLFLHHYLPALYFGILALGHFFEIFTGYLTSRSKYFQQVAFVLVGLFSILSLVFYVNYSSLIYGTPWTKASCELTKPFSGWDYNCGTFFDTLGEYDIQEKSLASESEIPTETVVVEAKQTPKAEPKLAKQDDHIESPAAAEPVEEKEVKEEVEQLAPPLAVDFEEETPKVEDPQVADVDASSNDEKSVEEKQQQEQQQEQEQVEDESVHQVQQ
Inhibitor
Name:
BDBM50149776
Synonyms:
CHEMBL367136 | {4-Oxo-5-[4-phenethyloxy-3-(1-phenyl-propoxy)-benzylidene]-2-thioxo-thiazolidin-3-yl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C29H27NO5S2
Mol. Mass.:
533.658
SMILES:
CCC(Oc1cc(\C=C2/SC(=S)N(CC(O)=O)C2=O)ccc1OCCc1ccccc1)c1ccccc1
Structure:
