Reaction Details Report a problem with these data
Target
Chemerin-like receptor 1
Ligand
BDBM50581657
Substrate
n/a
Meas. Tech.
ChEMBL_2151898 (CHEMBL5036445)
EC50
65±n/a nM
Citation
 Fischer, TF; Schoeder, CT; Zellmann, T; Stichel, J; Meiler, J; Beck-Sickinger, AG Cyclic Analogues of the Chemerin C-Terminus Mimic a Loop Conformation Essential for Activating the Chemokine-like Receptor 1. J Med Chem 64:3048-3058 (2021) [PubMed]  Article 
Target
Name:
Chemerin-like receptor 1
Synonyms:
CHEMR23 | CHEMR23 | CMKLR1 | CML1_HUMAN | Chemokine-like receptor 1 | DEZ | G-protein coupled receptor ChemR23 | G-protein coupled receptor DEZ
Type:
PROTEIN
Mol. Mass.:
42333.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100822
Residue:
373
Sequence:
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
  
Inhibitor
Name:
BDBM50581657
Synonyms:
CHEMBL5088494
Type:
Small organic molecule
Emp. Form.:
C55H66N10O12S2
Mol. Mass.:
1123.302
SMILES:
C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 |r|
Structure:
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