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Target
Adenosine kinase
Ligand
BDBM50117167
Substrate
n/a
Meas. Tech.
ChEMBL_305608 (CHEMBL828146)
IC50
22±n/a nM
Citation
 Gomtsyan, A; Didomenico, S; Lee, CH; Stewart, AO; Bhagwat, SS; Kowaluk, EA; Jarvis, MF Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors. Bioorg Med Chem Lett 14:4165-8 (2004) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50117167
Synonyms:
5-(3-Bromo-benzyl)-6-(6-morpholin-4-yl-pyridin-3-ylethynyl)-pyrimidin-4-ylamine | CHEMBL120650
Type:
Small organic molecule
Emp. Form.:
C22H20BrN5O
Mol. Mass.:
450.331
SMILES:
Nc1ncnc(C#Cc2ccc(nc2)N2CCOCC2)c1Cc1cccc(Br)c1
Structure:
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