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Target
C-X-C chemokine receptor type 1
Ligand
BDBM50150572
Substrate
n/a
Meas. Tech.
ChEMBL_306397 (CHEMBL828738)
IC50
22±n/a nM
Citation
 Weidner-Wells, MA; Henninger, TC; Fraga-Spano, SA; Boggs, CM; Matheis, M; Ritchie, DM; Argentieri, DC; Wachter, MP; Hlasta, DJ Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists. Bioorg Med Chem Lett 14:4307-11 (2004) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50150572
Synonyms:
1-(2-Bromo-phenyl)-3-(2,4-dihydroxy-phenyl)-urea | CHEMBL184637
Type:
Small organic molecule
Emp. Form.:
C13H11BrN2O3
Mol. Mass.:
323.142
SMILES:
Oc1ccc(NC(=O)Nc2ccccc2Br)c(O)c1
Structure:
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