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Target
Interleukin-17A
Ligand
BDBM50582227
Substrate
n/a
Meas. Tech.
ChEMBL_2153732 (CHEMBL5038279)
IC50
1.3±n/a nM
Citation
 Sabnis, RW Novel Difluorocyclohexyl Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Diseases. ACS Med Chem Lett 13:160-161 (2022) [PubMed]  Article 
Target
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Inhibitor
Name:
BDBM50582227
Synonyms:
CHEMBL5081660
Type:
Small organic molecule
Emp. Form.:
C28H33F6N7O4
Mol. Mass.:
645.5965
SMILES:
CNC(=O)[C@H](NC(=O)[C@@H](CC(F)(F)F)c1ccc2[nH]c(nc2c1F)[C@@H](NC(=O)c1nonc1C)C1CCC(F)(F)CC1)C(C)C |r|
Structure:
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