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Target
G-protein coupled receptor 6
Ligand
BDBM50582450
Substrate
n/a
Meas. Tech.
ChEMBL_2154540 (CHEMBL5039200)
Ki
9.4±n/a nM
Citation
 Sun, H; Monenschein, H; Schiffer, HH; Reichard, HA; Kikuchi, S; Hopkins, M; Macklin, TK; Hitchcock, S; Adams, M; Green, J; Brown, J; Murphy, ST; Kaushal, N; Collia, DR; Moore, S; Ray, WJ; English, NM; Carlton, MBL; Brice, NL First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate. J Med Chem 64:9875-9890 (2021) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM50582450
Synonyms:
CHEMBL4778540
Type:
Small organic molecule
Emp. Form.:
C24H29F2N5O3
Mol. Mass.:
473.5156
SMILES:
CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@@H]3CCOC3)nc2C1 |r|
Structure:
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