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Target
TGF-beta receptor type-1
Ligand
BDBM50151364
Substrate
n/a
Meas. Tech.
ChEMBL_305842 (CHEMBL829583)
IC50
>10000±n/a nM
Citation
 Gellibert, F; Woolven, J; Fouchet, MH; Mathews, N; Goodland, H; Lovegrove, V; Laroze, A; Nguyen, VL; Sautet, S; Wang, R; Janson, C; Smith, W; Krysa, G; Boullay, V; De Gouville, AC; Huet, S; Hartley, D Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem 47:4494-506 (2004) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Human
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50151364
Synonyms:
4-(pyridin-3-yl)-5-(quinolin-4-yl)thiazol-2-amine | 4-Pyridin-3-yl-5-quinolin-4-yl-thiazol-2-ylamine | CHEMBL359724
Type:
Small organic molecule
Emp. Form.:
C17H12N4S
Mol. Mass.:
304.369
SMILES:
Nc1nc(c(s1)-c1ccnc2ccccc12)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: