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Target
Dipeptidyl peptidase 2
Ligand
BDBM50151826
Substrate
n/a
Meas. Tech.
ChEMBL_305276 (CHEMBL832825)
IC50
50000±n/a nM
Citation
 Brockunier, LL; He, J; Colwell, LF; Habulihaz, B; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Teffera, Y; Wu, JK; Thornberry, NA; Weber, AE; Parmee, ER Substituted piperazines as novel dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett 14:4763-6 (2004) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 2
Synonyms:
DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase
Type:
Protein
Mol. Mass.:
54339.29
Organism:
Homo sapiens (Human)
Description:
Q9UHL4
Residue:
492
Sequence:
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
  
Inhibitor
Name:
BDBM50151826
Synonyms:
(R)-3-Amino-4-(2-fluoro-phenyl)-1-((R)-2-isopropyl-piperazin-1-yl)-butan-1-one | CHEMBL360488
Type:
Small organic molecule
Emp. Form.:
C17H26FN3O
Mol. Mass.:
307.4062
SMILES:
CC(C)[C@@H]1CNCCN1C(=O)C[C@H](N)Cc1ccccc1F
Structure:
Search PDB for entries with ligand similarity: