Reaction Details Report a problem with these data
Target
Small conductance calcium-activated potassium channel protein 2
Ligand
BDBM50583196
Substrate
n/a
Meas. Tech.
ChEMBL_2156785 (CHEMBL5041445)
EC50
>100000±n/a nM
Citation
 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K J Med Chem 65:303-322 (2022) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2)
Type:
Protein
Mol. Mass.:
63876.72
Organism:
Rattus norvegicus (Rat)
Description:
P70604
Residue:
580
Sequence:
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
  
Inhibitor
Name:
BDBM50583196
Synonyms:
CHEMBL5084004
Type:
Small organic molecule
Emp. Form.:
C16H23N5O
Mol. Mass.:
301.3867
SMILES:
Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](O)CC2)n1 |r,wD:14.14,17.18,(12.25,-10.26,;10.72,-10.43,;9.95,-11.76,;8.44,-11.44,;7.3,-12.48,;8.28,-9.91,;9.69,-9.28,;6.94,-9.15,;5.61,-9.92,;4.27,-9.15,;2.94,-9.92,;4.28,-7.61,;5.6,-6.84,;5.6,-5.3,;6.93,-4.52,;6.93,-2.98,;8.26,-2.21,;9.59,-2.97,;10.92,-2.2,;9.6,-4.51,;8.27,-5.29,;6.94,-7.6,)|
Structure:
Search PDB for entries with ligand similarity: