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Target
Small conductance calcium-activated potassium channel protein 2
Ligand
BDBM50583200
Substrate
n/a
Meas. Tech.
ChEMBL_2156785 (CHEMBL5041445)
EC50
>100000±n/a nM
Citation
 El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K J Med Chem 65:303-322 (2022) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2)
Type:
Protein
Mol. Mass.:
63876.72
Organism:
Rattus norvegicus (Rat)
Description:
P70604
Residue:
580
Sequence:
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
  
Inhibitor
Name:
BDBM50583200
Synonyms:
CHEMBL5093708
Type:
Small organic molecule
Emp. Form.:
C16H22FN5
Mol. Mass.:
303.3778
SMILES:
Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](F)CC2)n1 |r,wD:14.14,17.18,(87.17,-10.49,;85.64,-10.65,;84.87,-11.99,;83.37,-11.67,;82.22,-12.7,;83.2,-10.14,;84.61,-9.51,;81.87,-9.38,;80.53,-10.15,;79.2,-9.38,;77.86,-10.15,;79.2,-7.83,;80.53,-7.06,;80.52,-5.52,;81.85,-4.75,;81.85,-3.21,;83.18,-2.43,;84.52,-3.2,;85.85,-2.43,;84.52,-4.74,;83.19,-5.51,;81.86,-7.83,)|
Structure:
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