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Target
Tubulin beta-1 chain
Ligand
BDBM50152123
Substrate
n/a
Meas. Tech.
ChEMBL_302129 (CHEMBL841753)
Kd
700±n/a nM
Citation
 Zask, A; Birnberg, G; Cheung, K; Kaplan, J; Niu, C; Norton, E; Suayan, R; Yamashita, A; Cole, D; Tang, Z; Krishnamurthy, G; Williamson, R; Khafizova, G; Musto, S; Hernandez, R; Annable, T; Yang, X; Discafani, C; Beyer, C; Greenberger, LM; Loganzo, F; Ayral-Kaloustian, S Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286). J Med Chem 47:4774-86 (2004) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50152123
Synonyms:
4-({2-[3-(4-Methoxy-phenyl)-3-methyl-2-methylamino-butyrylamino]-3,3-dimethyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid | CHEMBL188372
Type:
Small organic molecule
Emp. Form.:
C28H45N3O5
Mol. Mass.:
503.674
SMILES:
CN[C@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)C(C)(C)c1ccc(OC)cc1
Structure:
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