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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50065258
Substrate
n/a
Meas. Tech.
ChEMBL_2157199 (CHEMBL5041859)
IC50
140±n/a nM
Citation
 Kato, A; Nakagome, I; Kanekiyo, U; Lu, TT; Li, YX; Yoshimura, K; Kishida, M; Shinzawa, K; Yoshida, T; Tanaka, N; Jia, YM; Nash, RJ; Fleet, GWJ; Yu, CY 5- J Med Chem 65:2329-2341 (2022) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase | FUCA1 | FUCO_HUMAN | Tissue alpha-L-fucosidase
Type:
PROTEIN
Mol. Mass.:
53690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34088
Residue:
466
Sequence:
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50065258
Synonyms:
(2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2S,3R,4S,5R)-2-methylpiperidine-3,4,5-triol | CHEMBL314772 | Fucosidase Inhibitor, 3
Type:
Small organic molecule
Emp. Form.:
C6H13NO3
Mol. Mass.:
147.1723
SMILES:
C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Structure:
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