Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50152511
Substrate
n/a
Meas. Tech.
ChEMBL_303669 (CHEMBL830430)
Ki
1200±n/a nM
Citation
 Torisu, K; Kobayashi, K; Iwahashi, M; Nakai, Y; Onoda, T; Nagase, T; Sugimoto, I; Okada, Y; Matsumoto, R; Nanbu, F; Ohuchida, S; Nakai, H; Toda, M Discovery of orally active prostaglandin D2 receptor antagonists. Bioorg Med Chem Lett 14:4891-5 (2004) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_MOUSE | PGE receptor, EP3 isoform alpha | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor | Ptger3 | Ptgerep3
Type:
G-protein coupled receptor
Mol. Mass.:
40092.50
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
365
Sequence:
MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
  
Inhibitor
Name:
BDBM50152511
Synonyms:
CHEMBL365243 | [1-(4-Benzyloxy-benzoyl)-2-methyl-1H-indol-4-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C25H21NO4
Mol. Mass.:
399.4385
SMILES:
Cc1cc2c(CC(O)=O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: