Reaction Details Report a problem with these data
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM50583532
Substrate
n/a
Meas. Tech.
ChEMBL_2157652 (CHEMBL5042312)
Ki
41±n/a nM
Citation
 Guo, M; He, S; Cheng, J; Li, Y; Dong, G; Sheng, C Hydrophobic Tagging-Induced Degradation of PDE? in Colon Cancer Cells. ACS Med Chem Lett 13:298-303 (2022) [PubMed]  Article 
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Inhibitor
Name:
BDBM50583532
Synonyms:
CHEMBL5079726
Type:
Small organic molecule
Emp. Form.:
C33H44N6O3
Mol. Mass.:
572.7409
SMILES:
Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCC(=O)NCC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:26:27:24.25.30:31,THB:26:25:31:32.27.28,28:27:24:30.29.31,28:29:24:32.26.27|
Structure:
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