Reaction Details Report a problem with these data
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM50583533
Substrate
n/a
Meas. Tech.
ChEMBL_2157652 (CHEMBL5042312)
Ki
9.3±n/a nM
Citation
 Guo, M; He, S; Cheng, J; Li, Y; Dong, G; Sheng, C Hydrophobic Tagging-Induced Degradation of PDE? in Colon Cancer Cells. ACS Med Chem Lett 13:298-303 (2022) [PubMed]  Article 
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Inhibitor
Name:
BDBM50583533
Synonyms:
CHEMBL5084153
Type:
Small organic molecule
Emp. Form.:
C29H37N5O2
Mol. Mass.:
487.6364
SMILES:
Cc1n(nc2c1c(C)nn(CCCC(=O)NCC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:20:21:18.19.24:25,THB:20:19:25:26.21.22,22:21:18:24.23.25,22:23:18:26.20.21|
Structure:
Search PDB for entries with ligand similarity: