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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50152950
Substrate
n/a
Meas. Tech.
ChEMBL_306337 (CHEMBL828157)
IC50
150±n/a nM
Citation
 Boy, KM; Dee, M; Yevich, J; Torrente, J; Gao, Q; Iben, L; Stark, A; Mattson, RJ Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity. Bioorg Med Chem Lett 14:4467-70 (2004) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50152950
Synonyms:
4-[4-(2-methoxybenzyl)hexahydro-1-pyridinyl]spiro[cyclohexane-1,6''-(6'',8''-dihydro[1,3]dioxolo[5,4-e]isobenzofuran)]-8''-one | CHEMBL363768
Type:
Small organic molecule
Emp. Form.:
C27H31NO5
Mol. Mass.:
449.5387
SMILES:
COc1ccccc1CC1CCN(CC1)[C@H]1CC[C@]2(CC1)OC(=O)c1c3OCOc3ccc21 |wU:15.16,18.23,(5.77,-5.97,;7.19,-5.39,;7.41,-3.88,;8.84,-3.29,;9.05,-1.76,;7.82,-.82,;6.4,-1.41,;6.19,-2.94,;4.76,-3.51,;3.54,-2.57,;2.12,-3.15,;.92,-2.2,;1.12,-.68,;2.55,-.1,;3.76,-1.03,;-.09,.26,;-1.52,-.33,;-2.74,.6,;-2.54,2.14,;-1.12,2.73,;.1,1.8,;-2.51,3.68,;-3.96,4.19,;-4.8,5.49,;-4.89,2.98,;-6.43,2.84,;-7.55,3.92,;-8.9,3.19,;-8.62,1.68,;-7.1,1.46,;-6.24,.21,;-4.7,.3,;-4.01,1.7,)|
Structure:
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