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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50152955
Substrate
n/a
Meas. Tech.
ChEMBL_306337 (CHEMBL828157)
IC50
45±n/a nM
Citation
 Boy, KM; Dee, M; Yevich, J; Torrente, J; Gao, Q; Iben, L; Stark, A; Mattson, RJ Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity. Bioorg Med Chem Lett 14:4467-70 (2004) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50152955
Synonyms:
4-[4-(2-bromobenzyl)hexahydro-1-pyridinyl]spiro[cyclohexane-1,6''-(6'',8''-dihydro[1,3]dioxolo[5,4-e]isobenzofuran)]-8''-one | CHEMBL185540
Type:
Small organic molecule
Emp. Form.:
C26H28BrNO4
Mol. Mass.:
498.409
SMILES:
Brc1ccccc1CC1CCN(CC1)[C@H]1CC[C@]2(CC1)OC(=O)c1c3OCOc3ccc21 |wU:14.15,17.22,(7.38,-5.58,;7.59,-4.06,;9.01,-3.47,;9.22,-1.94,;8,-1,;6.57,-1.59,;6.37,-3.11,;4.95,-3.69,;3.73,-2.76,;3.94,-1.22,;2.73,-.29,;1.31,-.86,;1.1,-2.39,;2.31,-3.34,;.08,.07,;-1.34,-.52,;-2.56,.41,;-2.35,1.95,;-.93,2.54,;.28,1.6,;-2.32,3.5,;-3.78,4,;-4.62,5.31,;-4.71,2.79,;-6.25,2.67,;-7.36,3.73,;-8.72,3,;-8.46,1.49,;-6.92,1.27,;-6.06,.02,;-4.52,.13,;-3.84,1.51,)|
Structure:
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