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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50152951
Substrate
n/a
Meas. Tech.
ChEMBL_306337 (CHEMBL828157)
IC50
5±n/a nM
Citation
 Boy, KM; Dee, M; Yevich, J; Torrente, J; Gao, Q; Iben, L; Stark, A; Mattson, RJ Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity. Bioorg Med Chem Lett 14:4467-70 (2004) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50152951
Synonyms:
(S)-4-[4-(2,5-Difluoro-benzyl)-piperidin-1-yl]-1,2,3,4-tetrahydro-8,10-dioxa-6-aza-cyclopenta[b]phenanthren-5-ol | (S)-4-[4-(2,5-Difluoro-benzyl)-piperidin-1-yl]-2,3,4,6-tetrahydro-1H-8,10-dioxa-6-aza-cyclopenta[b]phenanthren-5-one | CHEMBL180899
Type:
Small organic molecule
Emp. Form.:
C26H26F2N2O3
Mol. Mass.:
452.493
SMILES:
Fc1ccc(F)c(CC2CCN(CC2)[C@H]2CCCc3c2c(=O)[nH]c2cc4OCOc4cc32)c1
Structure:
Search PDB for entries with ligand similarity: