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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50152939
Substrate
n/a
Meas. Tech.
ChEMBL_306337 (CHEMBL828157)
IC50
73±n/a nM
Citation
 Boy, KM; Dee, M; Yevich, J; Torrente, J; Gao, Q; Iben, L; Stark, A; Mattson, RJ Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity. Bioorg Med Chem Lett 14:4467-70 (2004) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50152939
Synonyms:
4-[4-(2-bromobenzyl)hexahydro-1-pyridinyl]spiro[cyclohexane-1,7''-(2'',3'',7'',9''-tetrahydro[1,4]dioxino[3,2-e]isobenzofuran)]-9''-one | CHEMBL363320
Type:
Small organic molecule
Emp. Form.:
C27H30BrNO4
Mol. Mass.:
512.435
SMILES:
Brc1ccccc1CC1CCN(CC1)[C@H]1CC[C@]2(CC1)OC(=O)c1c2ccc2OCCOc12 |wU:14.15,17.22,(7.84,-5.7,;7.86,-4.16,;9.29,-3.57,;9.49,-2.05,;8.26,-1.1,;6.84,-1.68,;6.64,-3.2,;5.22,-3.78,;3.99,-2.85,;4.2,-1.33,;2.99,-.37,;1.57,-.96,;1.36,-2.49,;2.57,-3.43,;.35,-.03,;-1.07,-.61,;-2.3,.32,;-2.09,1.86,;-.67,2.44,;.54,1.51,;-2.05,3.4,;-3.51,3.92,;-4.35,5.2,;-4.44,2.7,;-3.57,1.42,;-4.26,.02,;-5.8,-.05,;-6.66,1.18,;-8.2,1.09,;-9.05,2.35,;-8.38,3.75,;-6.83,3.85,;-5.98,2.58,)|
Structure:
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